For instance, the pre-infection of tomato cultivars that carry the Sw-5 gene (which confers broad-spectrum resistance to tospoviruses through the recognition of a conserved 21-amino acid viral epitope [28]) with tomato chlorosis virus (ToCV, a crinivirus) results in susceptibility to tomato spotted wilt virus (TSWV, a tospovirus) [246]. The gene discussed is SLC4A1; the disease is infection.