In conclusion, our study is the first report to show that HD significantly suppressed OVA-induced lung inflammation, lymphocytes, eosinophils infiltration, and AHR in an asthmatic mouse model of allergic asthma by the inhibition of Th2 cytokines (IL-5 and IL-13) by the GATA-3 (high) and pSTAT6 (low) transcription pathways. Here, GATA3 is linked to Huntington disease.