Interferon (IFN)-γ, IL-4, IL-6, IL-8, regulated on activation-normal T cell expressed and secreted (RANTES), stem cell factor (SCF), and monocyte chemoattractant protein (MCP) -1 were significantly lower on day 6 than on day 0 in cats with severe oral disease (Table 5). Here, CXCL8 is linked to mouth disorder.