Many evidences suggested that CCNB2 expression was increased in a variety of human cancers, such as non-small cell lung cancer[31], breast carcinoma[26], gastric cancer[32], colorectal adenocarcinoma[33], pituitary adenoma[34] and adrenocortical carcinoma[35]. The gene discussed is CCNB2; the disease is adrenal cortex carcinoma.