Two independent lines of Adora1−/− mice also show decreased survival (https://www.jax.org/strain/014161 and George Yuning Huang, National Institute of Diabetes and Digestive and Kidney Diseases, personal communication); to our knowledge, decreased survival has not been reported for Adora2a−/−, Adora2b−/−, or Adora3−/− mice. Here, ADORA3 is linked to kidney disorder.