CACNA1C and diabetes mellitus: LTCC activity is critical for vascular reactivity (Knot and Nelson, 1998), and its function is enhanced in response to acute increases in glucose and in diabetes due to increased Ser1928 phosphorylation in the CaV1.2 carboxy terminal (Morotti et al., 2017; Navedo et al., 2010b; Nystoriak et al., 2017).