Furthermore, the prepared compounds were screened for their inhibitory activities against certain phospholipases including, hG-IIA, hG-V, hG-X, NmPLA2, and AmPLA2, and five proteases namely, cathepsin-B, collagenase, thrombin, elastase, and trypsin, in addition to three enzymes involved in metabolic syndrome namely, α-amylase, α-glucosidase, and xanthine oxidase. Here, CTSB is linked to metabolic syndrome.