Moreover, pharmacological PKR inhibition can reduce IL‐1β levels in a rat model of excitotoxicity and neuroinflammation (Tronel, Page, Bodard, Chalon, & Antier, 2014), but our results show for the first time that PKR genetic blockade reduces neuroinflammation in an AD transgenic mice model. The gene discussed is EIF2AK2; the disease is Alzheimer disease.