Later, Baptiste et al. (9) described several steps for the appearance of PCOS: (a) enzymatic default in the ovarian and/or adrenal steroidogenesis; (b) variation in the gonadotropin-releasing hormone that encourages luteal hormone secretion; or (c) amendments in insulin actions leading to insulin resistance with compensatory hyperinsulinemia. The gene discussed is INS; the disease is polycystic ovary syndrome.