Investigating the potential differences in ATX levels at baseline between patient subgroups, we found differences according to sex (Fig. 1A, 244.7 ± 67.8 in men vs. 366.5 ± 164.1 pg/mL in women; P = 0.0002) but not according to T2D status (Fig. 1B), even when considering men and women separately (Fig. 1C). Here, ENPP2 is linked to type 2 diabetes mellitus.