To determine if acute changes in ATX levels after bariatric surgery were related to the CR induced by BPD‐DS surgery, seven participants with severe obesity and T2D were submitted to a 3‐day CR protocol prior to their bariatric surgery that matched the energy intake that we generally observe during the 3 days after BPD‐DS surgery. This evidence concerns the gene ENPP2 and obesity due to melanocortin 4 receptor deficiency.