2000). Work from Bouchareb et al. (2015) recently showed that lyso‐PA derived from ATX promotes inflammation and the development of calcific aortic valve stenosis (CAVS). Moreover, the ATX‐lyso‐PA axis has been involved in other disorders such as hepatic steatosis (Rachakonda et al. 2015), cancer (Liu et al. 2009; Barbayianni et al. 2015) and atherosclerosis (Smyth et al. 2014). Here, ENPP2 is linked to atherosclerosis.