Older lung adenocarcinoma patients carried more mutations in the genes SMORF1, TP53, ZFHX4, ZNF493, AFF1, BCLAF1, CASP5, RPTN, USH2A, LRP1B, GOLGA6L2, and EGFR than YLAPs (Figure 1, Tables S1 and S2). The gene discussed is LRP1B; the disease is lung adenocarcinoma.