Older lung adenocarcinoma patients carried more mutations in the genes SMORF1, TP53, ZFHX4, ZNF493, AFF1, BCLAF1, CASP5, RPTN, USH2A, LRP1B, GOLGA6L2, and EGFR than YLAPs (Figure 1, Tables S1 and S2). The gene discussed is AFF1; the disease is lung adenocarcinoma.