In addition, YAP/TAZ activation in tumour cells is promoted by increased levels of mevalonic acid produced by SREBPs transcriptional activity, which is induced by its oncogenic cofactor mutant p53.17 Furthermore, Lats2, a component of Hippo signalling, has been shown to suppress hepatic cholesterol accumulation by inhibiting SREBPs. This evidence concerns the gene TP53 and neoplasm.