The Hippo pathway was initially defined by genetic studies in Drosophila melanogaster, which is an evolutionarily conserved controller of both cell proliferation and apoptosis.7 Sterile 20‐like kinases Mst1 and Mst2 (Hippo in Drosophila), large tumour suppressors Lats1 and Lats2 (Warts in Drosophila), Yes‐associated protein YAP (Yorkie from Drosophila) and its PDZ‐binding motif‐containing paralogue TAZ represent the core components of the mammalian Hippo pathway. This evidence concerns the gene LATS1 and neoplasm.