YAP1 and obesity due to melanocortin 4 receptor deficiency: The diabetogenic diet composed of high fat and high sucrose (HFHS), previously described to promote obesity and type 2 diabetes in C57BL/6 mice, could induce hepatic steatosis, hyperlipidaemia, insulin resistance and enhanced atherosclerotic plaques in mice.27, 28 In order to explore the phosphorylation status of YAP in diabetic mice, C57BL/6 mice were placed on either a normal chow diet or a HFHS diet for 16 weeks.