YAP1 and neoplasm: Western blot was also performed and reflected that, in diabetic mice, the YAP protein was increased and dephosphorylated at serine 127 (Figure 2B), which promotes YAP nuclear translocation and activation.7 Furthermore, we cultured the primary hepatocytes of mice and stimulated the cells with mevalonic acid (MVA), which was accumulated in diabetic mice and reported to induced YAP nuclear localization and activation in tumour cells.