In a recent research, Lats2 was shown to inhibit SREBPs and suppresses hepatic cholesterol accumulation through a Lats2‐p53 axis.35 Mice harbouring liver‐specific Lats2 conditional knockout displayed SREBP activation, leading to spontaneous fatty liver disease.35 Furthermore, only Lats2, not Lats1, could inhibit SREBPs and suppress hepatic cholesterol accumulation. Here, TP53 is linked to fatty liver disease.