As important metabolic transcription factors, SREBPs play critical roles in the lipogenesis and cholesterol synthesis through activating the relevant enzymes in the insulin resistance mice.32 We have been suggested that the phenotypic alterations of ad‐Lats1 or sh‐YAP–treated mice might be owed to the inhibition of hyperactive SREBPs in hepatocytes. This evidence concerns the gene YAP1 and Insulin resistance.