For example, fenretinide induces apoptosis of Huh7 cells through NR4A1 induction and cytoplasmic translocation, whereas fenretinide could not induce apoptosis of HepG2 cells seemingly due to NR4A1 accumulation in the nucleus.35 Tumour necrosis factor‐α‐induced NR4A1 expression and nuclear accumulation reduce its apoptotic effects in breast cancer cells.19 In our study, we found that NR4A1 was highly expressed in TRAIL‐resistant HCC cells. This evidence concerns the gene NR4A1 and breast carcinoma.