Knock‐down of Xaf1 in glioblastoma cell lines led to the complete loss of IFN‐β‐mediated TRAIL sensitivity, thereby indicating that Xaf1 was a crucial ISG and played key roles in TRAIL‐induced cell death.9 The FAM14 family member G1P3 is another ISG that antagonized TRAIL‐induced apoptosis through the inhibition of intrinsic apoptotic pathway.10 The gene discussed is TNFSF10; the disease is glioblastoma.