IFI27 and cancer: Unlike the anti‐apoptotic function of G1P3, ISG12a exerts pro‐apoptotic effects on cancer cells.11, 12 ISG12a localizes to the mitochondria, nuclear membrane and endoplasmic reticulum in different cell lines.11, 12, 14, 15 The different subcellular distributions of ISG12a suggest that it may have diverse biological functions.