XAF1 and glioblastoma: Knock‐down of Xaf1 in glioblastoma cell lines led to the complete loss of IFN‐β‐mediated TRAIL sensitivity, thereby indicating that Xaf1 was a crucial ISG and played key roles in TRAIL‐induced cell death.9 The FAM14 family member G1P3 is another ISG that antagonized TRAIL‐induced apoptosis through the inhibition of intrinsic apoptotic pathway.10