It was previously reported that TRAIL‐induced activation of NF‐κB pathway was responsible for HCC cells resistance to TRAIL‐induced apoptosis.24 Another study demonstrated that TRAIL can induce apoptosis through activation of JNK in HCC cells.25 According to the abovementioned studies, we have been suggested that TRAIL may activate different pathways in TRAIL‐sensitive and TRAIL‐resistant cells. Here, TNFSF10 is linked to hepatocellular carcinoma.