Backward elimination regression analysis for cognitive impairment defined by the neuropsychological tests revealed the following predictors, after adjusting for age and gender: CSF Aβ42 (hazard ratio [HR]: 0.996, Wald: 5.035, confidence interval [CI]: 0.992–0.999, p = 0.025), CSF total tau ([HR]: 1.023, Wald: 4.680, [CI]: 1.002–1.044, p = 0.031) and caudate [123I]FP-CIT uptake ([HR]: 0.332, Wald: 4.146, [CI]: 0.115–0.960, p = 0.042; Table 2). This evidence concerns the gene MAPT and Cognitive impairment.