In accordance with studies in other cancers (Berger et al. 2013; Song et al. 2012; Wang et al. 2013), knocking down FLOT1 and/or FLOT2 inhibited the invasion, migration, and anchorage-independent growth of HCCLM3 cells in vitro and decreased their tumor growth and metastasis in vivo. Here, FLOT2 is linked to cancer.