PYGL and colorectal carcinoma: Similarly, for PYGL, the CRC association with genetically regulated gene expression had an OR of 0.89 (95% CI 0.82–0.97, P = 3 × 10− 3) in proximal colon cases compared to an OR of 0.91 (95% CI 0.83–1.0, P = 2 × 10− 2) in distal colon cases and an OR of 0.86 (95% CI 0.77–0.95, P = 5 × 10− 4) in rectal cases with no significant difference in effects (Q test for heterogeneity P = 0.98).