For TRIM4, the CRC association with genetically imputed gene expression had an OR of 0.94 (95% CI 0.90–0.98, P = 3 × 10− 3) in proximal colon cases compared to an OR of 0.95 (95% CI 0.90–1.0, P = 5 × 10− 2) in distal colon cases and an OR of 0.93 (95% CI 0.88–0.98, P = 2 × 10− 2) in rectal cases. Here, TRIM4 is linked to colorectal carcinoma.