Bioinformatic follow-up of the TRIM4 locus showed that in the genomic region containing variants correlated with rs2527886, there were six enhancers with strong Chromatin Immunoprecipitation Sequencing (ChIP-seq) H3K27ac signal in either normal colorectal crypt cells or a CRC cell line (Online Resource 1 Fig S3). Here, TRIM4 is linked to colorectal carcinoma.