Among the 34 regions containing associated genes, we found that the most significant gene association in the PrediXcan analysis was often the strongest candidate based on either known CRC etiology and gene function or results from previous laboratory follow-up (e.g. COLCA2, LAMC1, POLD3, SMAD7, TGFB1). This evidence concerns the gene TGFB1 and colorectal carcinoma.