High expression levels of ROBO3 and ROBO4 RNA were noted in poor Cancer and Leukemia Group B (CALGB) cytogenetic risk group of patients in comparison with normal and favorable risk groups (p = 0.0029 and p = 0.0003, respectively, from ANOVA-Kruskall–Wallis test) (Fig. 10). Here, ROBO4 is linked to cancer.