Overall, by analyzing cancer biclusters, we were able to identify the key pathways (PI3K/Akt signaling, ECM and focal adhesion), and five associated prognostic miRNAs (miR-29a, miR-29b and miR-29c in breast cancer; miR-34a and miR-145 in DLBCL) that are repressive of tumor progression (hazard ratios of 0.593–0.745). This evidence concerns the gene AKT1 and neoplasm.