THBS2 and cancer: In both cancer types, the miRNAs targeted multiple ligands including genes encoding growth factors (e.g. VEGFA and PDGFC targeted by miR-29) and ECM (e.g. COL1A1, LAMC1 and THBS2 by miR-29); signal transducers such as receptor tyrosine kinase (e.g. MEK and/or PDGFRA by miR-34a), G-proteins (GNB4 and GNG12 by miR-29), toll-like receptor (TLR4 by miR-34a and miR-145) and integrin (e.g. ITGB1 by miR-29); as well as downstream effectors such as NRAS (by miR-29 and miR-145) and CDK6 (by miR-29).