Previous evidence suggested that several lncRNAs, including NKILA (36), lincRNA-p21 (37) and HOTAIR (38), regulated NF-κB signal in cancer and rheumatoid arthritis, by inhibiting IKK-induced IκB phosphorylation, interacting with p65 mRNA to inhibit translation or decreasing the level of IκB. This evidence concerns the gene HOTAIR and cancer.