Bayrak et al. and Gulluoglu et al. suggest that miRNA 31-3p, 148a, and 222-3p impose a pro-apoptotic effect on chordoma by regulating Met and Radixin oncogenes, DNA methyltransferase (DNMT) pro-apoptotic gene, and c-KIT proto-oncogene respectively, subsequently inducing a cell cycle arrest at the S-phase and preventing progression to G2 phase [3-4,15-16]. The miRNAs are also expressed varyingly in different chordoma cell lines. This evidence concerns the gene RDX and chordoma.