CD274 and hypothyroidism: Herein, we report a case of worsening hypothyroidism in a patient with advanced urothelial cancer treated with AZD4547.<h4>Case presentation</h4>An 80-year-old Caucasian female with metastatic urothelial carcinoma failed first-line chemotherapy with gemcitabine and carboplatin and second-line treatment with atezolizumab, an inhibitor of programmed cell death ligand 1.