Indeed, protection against malaria has been correlated to CSPf CD8+ T cell response in human immune system (HIS) mice harboring functional human CD8+ T cells.38 This major role for CD8+ T cells to induce protection was already shown by in vivo depletion of CD8+ T cells that abrogated sporozoïte-induced protective immunity in mice.39 Thus, even if the protection resulting from rGFP-PbA-CSPf repeated challenge model was not indicative of real protection, it brought indications of efficient immune mechanisms involved in protection. This evidence concerns the gene CD8A and malaria.