In fact, phagocytic activity of antibodies induced by RTS,S/AS01 malaria vaccine has been correlated with full-length CS and C-terminal-specific antibody titer, but not to repeat region antibody titer.37 Accordingly, we showed a moderate but significant induction of cell-mediated immune response that appeared as early as 7 days after a single immunization, with an increase in CD4+ and CD8+-specific T cells secreting IFNγ or TNFα. Here, CD4 is linked to malaria.