BRAF and melanoma: Among our top-ranked drug combination pairs involving BRAF inhibitors, several drug combinations were previously validated in preclinical and clinical studies, including celecoxib (COX-2 nonsteroidal anti-inflammatory),43 dasatinib (Src family kinase inhibitor),44 and decitabine (cytotoxic chemotherapy).45 In this study, we demonstrated experimental evidence validating the drug combination of vemurafenib and tretinoin (ATRA), which was the top-ranked prediction involving BRAF inhibitors for BRAF-mutant melanoma by our method.