BRAF and melanoma: In our previous work, we tested SynGeNet in a limited setting exclusively in BRAF-mutant melanoma and showed that it could outperform several other tools that use disease- and drug-associated gene expression data to generate drug combination predictions.34 In this study, we systematically expand and evaluate SynGeNet to predict synergistic drug combinations for all four genomic subtypes of melanoma, as well as interpret mechanisms of SynGeNet predictions.