In a homogenous group of Sardinian β0-thalassemic patients, Galenello et al. [43] reported that all this group (50 cases of TI and 75 cases of TM) was negative for the XmnI SNP (HBG2) and their mild thalassemic phenotype could be mostly attributed to the co-inheritance of BCL11A, HBS1L-MYB SNPs as well as to α-thalassemia mutations. This evidence concerns the gene HBG2 and thalassemia.