TNF and Sepsis: Serum levels of TNF-a, IL-6, and IL- 10 at 6 h and 30 h were significantly elevated in CLP-induced sepsis in comparisons with those in the sham group (p < 0.05), serum levels of TNF-a, IL-6, and IL- 10 of LDK378 group at 54 h were higher than sham group (p < 0.05).