BGLAP and cancer: This intronic CpG site overlaps with the binding site for an oncogenic transcription factor, JunD, which promotes cancer cell proliferation.33 In addition, the molecular subtype, as inferred using Absolute Intrinsic Molecular Subtyping (AIMS) method,30 was strongly associated with OC overexpression (two-way analysis of variance (ANOVA), F(1, 107), AIMS: P-value = 8.9 × 10−4, intronic CpG methyl: P-value = 1.4 × 10−9) (Supplementary Figure 7).