For example, an LMR detected only in RA samples was located in the first intron of the endothelial PAS domain-containing protein 1 (EPAS1) gene, often known as hypoxia inducible factor 2 (HIF2A), which is a pivotal component in RA pathogenesis34 (Fig. 3c). Here, EPAS1 is linked to rheumatoid arthritis.