In summary, genetic obesity is associated with hyperinsulinaemia, dyslipidaemia and increased pancreatic expression of Cyp27A1, ADXR, TSPO and LXRα, while overexpression of Cyp27A1 and/or its redox partners promotes the expression of ABCA1 and enhances cholesterol efflux from insulin-secreting cells to apoA-I and HDL. The gene discussed is APOA1; the disease is inherited lipid metabolism disorder.