Underpinning its importance, loss of NSL complex members leads to lethality during early development in flies (Raja et al. 2010), whereas heterozygous mutations in NSL1 and NSL2 orthologs KANSL1 and KANSL2 underlie intellectual disability in humans (Koolen et al. 2012; Zollino et al. 2012; Gilissen et al. 2014). Here, KANSL2 is linked to Intellectual disability.