We have also observed additional individuals presenting with neurodevelopmental disorders of variable severity from our clinical database, carrying de novo truncating variants (n = 6, Fig. 1, in green), deletions (n = 1, de novo, Fig. 3), and duplications (n = 3, Fig. 3) involving TCF20. These individuals are included in this study as anonymized subjects (Figs. 1 and 3). The gene discussed is TCF20; the disease is neurodevelopmental disorder.