SST and depressive disorder: Reduced expression of somatostatin (SST)-containing GABA-ergic interneurons has also been reported in the postmortem brains of human patients with MDD [112, 113] and mouse models of depression [114], with disinhibition of SST-containing GABA-ergic interneurons using Cre recombinase resulting in anxiolytic and antidepressant effects in mice, without impairing spatial learning and memory [115].