Moreover, downregulation of RBMS3 in esophageal squamous cell carcinoma [18], lung squamous cell carcinoma [19], nasopharyngeal carcinoma [20] and gastric carcinoma [21] are frequently correlated with poor prognosis in patients and loss of RBMS3 contributed to chemoresistance in epithelial ovarian cancer [22]. Here, RBMS3 is linked to esophageal squamous cell carcinoma.