To explore the role of TRPM7 in the development and progression of ovarian cancer, SKOV3 and OVCAR3 cells were transfected with plasmid for control shRNA or TRPM7-sepcific shRNA that displayed the best effect on reducing TRPM7 expression in our experimental system (Fig. 2 and Additional file 2 Figure S1A). Here, TRPM7 is linked to ovarian cancer.