The correlation analysis between the AFAP1-AS1 expression and the characteristics of PC patients (Table 2) demonstrated that the expression of AFAP1-AS1 was not correlated with the gender, age, local infiltration and differentiation degree (p > 0.05), however a positive correlation to TNM stage, lymph node metastasis, and tumor size was observed (p < 0.05), suggesting that AFAP1-AS1 expression is positively correlated with the PC progression. The gene discussed is AFAP1; the disease is pachyonychia congenita.