In PC, the expression of miR-384 has been previously demonstrated to be inhibited by lncRNA colorectal neoplasia differentially expressed (CRNDE), which on the whole enhanced PC cells proliferation and metastasis by up-regulating insulin receptor substrate 1 (IRS1) through competitively binding to miR-384 [32]. The gene discussed is IRS1; the disease is pachyonychia congenita.