ACVR1 was further highlighted as a regulator of stem cell markers, with the hepatocellular carcinoma CSC subtype featured by the miR-148a-ACVR1-bone morphogenetic protein (BMP)-Wnt circuit, whereby the expression of ACVR1 was suppressed by miR-148a [14]. Here, ACVR1 is linked to hepatocellular carcinoma.