We have already demonstrated that CSF profiles differ significantly between MS and NMOSD [2, 3], MS and BCS [33], MS and MOG-EM [10, 11, 35, 36] and between biopsied/autopsied patients with suspected MS and so-called pattern 1 brain lesions on the one hand and patients with so-called pattern 2 or 3 brain lesions on the other [8] (Fig. 1). This evidence concerns the gene MOG and myeloid sarcoma.