SLC5A1 and hyperinsulinism: Although the reason for the divergent SGLT-1 expression in type 1 and type 2 diabetes is uncertain, it seems conceivable that increased SGLT-1 may be related to Free Fatty Acid-induced insulin-resistance, with increased SGLT-1 as an adaptation to the known reduction in cardiac GLUT1 and GLUT4 expression, resulting in hyperinsulinemia [29].