KRAS and cancer: To determine the role of HFD in oncogenic KRAS-mediated aerobic glycolysis in cancer, we employed the KrasLSL-G12D/+;fElasCreERT mouse model that expresses mutant KrasG12D in one allele at an endogenous level in nearly 100% acinar cells upon tamoxifen induction (hereafter called KrasG12D/+) [11, 12, 15].