Of note, monoclonal antibody ramucirumab and tyrosine kinase inhibitor apatinib, both targeting VEGFR2, showed more favourable benefit compared to direct block of angiogenesis stimuli by bevacizumab [4], implying the complicated implication of VEGFR2 involved in tumorigenesis and progression of gastric cancer. The gene discussed is KDR; the disease is gastric cancer.