KDR and spindle cell hemangioma: To determine whether VEGFR2 expression is required for gastric cancer growth and metastasis, we knocked down VEGFR2 with specific shRNAs in MKN-45 cells (Fig. 2c & d), which have a high level of VEGFR2, and overexpressed VEGFR2 by cDNA construct transfection in SCH cells (Fig. 2l & m), which have a low level of VEGFR2.