The cell surface receptor tyrosine kinase c-Met, usually only present in progenitor and stem cells for the purpose of organogenesis and wound healing, is abnormally high in cholangiocarcinoma along with its only known ligand Hepatocyte Growth Factor (HGF) leading to tumour growth, angiogenesis and metastasis [149, 150]. Here, HGF is linked to cholangiocarcinoma.