Methylation profiles comparing buccal epithelial swabs and bronchial epithelium obtained from individuals with adenocarcinoma lung cancers who smoke tobacco, to assess the utility of saliva for screening and diagnosing lung cancer found the methylation profiles of two genes involved in early lung carcinogenesis, p16 and FHIT, correlated strongly between saliva and bronchial samples [21]. Here, FHIT is linked to adenocarcinoma.