Similarly, a study in renal cell carcinoma (RCC) identified the miR-143/145 cluster to be downregulated in RCC tissues when compared to adjacent non-cancerous tissues, with significantly higher HKII levels in RCC tissues as compared to non-cancerous tissues, confirming the tumour suppressive effect of the miR-143/145 cluster through targeting HKII [48]. This evidence concerns the gene HK2 and renal cell carcinoma.