q-PCR analysis of HKII mRNA transcript expression showed increased levels of HKII mRNA transcript in the four patient-derived NHL cell lines (SU-DHL-4, Raji, Mino, and Toledo) when compared to lymphocytes that are derived from two healthy control subjects, however the differences in expression levels were not statistically significant (Figure 2). Here, HK2 is linked to non-Hodgkin lymphoma.