miR-143, an essential regulator of glycolysis [43], inhibits HKII expression by binding to a conserved recognition motif that is located in the 3′-UTR of HKII mRNA and has been observed to be inversely correlated with HKII levels in primary keratinocytes and in head and neck squamous cell carcinoma (HNSCC)-derived cell lines [44]. The gene discussed is HK2; the disease is head and neck squamous cell carcinoma.