As HKII is a known target gene for mature hsa-miR-143 (miR-143), our secondary aim examined HKII expression in four patient-derived NHL cell lines, as compared to a metastatic breast cancer (MDA-MB-231) and melanoma (MDA-MB-435) cell line, as well as two healthy control subjects to assess the potential functional link between miR-143 regulation and HKII levels in NHL. The gene discussed is HK2; the disease is melanoma.