This result suggests that CD44-targeted liposomes involve receptor-mediated endocytosis with additional membrane fusion of lipid bilayers, resulting in a higher cellular uptake, as previously described that CD44 upregulation in the cancer cells assisted endocytosis via independent clathrin-coated vesicles, the caveolae or macropinocytosis pathway [34,35,36]. The gene discussed is CD44; the disease is cancer.