In this study, we improved the preparation of gPTX-L to achieve higher encapsulation efficiency (EE) and designed gPTX-IL, gPTX-L bound to anti-human CD44 monoclonal antibody (anti-hCD44 MAb) to target CD44 overexpressing ovarian cancer cells evaluating the physical parameters of liposome and the efficacy of gPTX-IL targeting CD44 positive ovarian cancer cells. The gene discussed is CD44; the disease is ovarian cancer.