In addition, diverse renal cells (endothelial, epithelial, mesangial, and tubular cells) are also capable of synthesizing other proinflammatory cytokines such as tumor necrosis factor (TNF)α, IL1, and IL6, and therefore these cytokines, acting in a paracrine or autocrine manner, may induce a variety of effects on different renal structures [33,34] playing a significant role in pathophysiology of DKD. This evidence concerns the gene IL6 and diabetic kidney disease.