Our previous studies on HT-29 colon carcinoma cells with Snail overexpression, which mimic colon cancer cells at the early stage of the EMT, proved that HT-29/Snail cells have a higher migratory rate than normal HT-29 cells; however, no upregulation or enhanced activity of MMP-2 or MMP-14 was observed [9,34]. The gene discussed is SNAI1; the disease is colon carcinoma.