INS and obesity due to melanocortin 4 receptor deficiency: These results seem to be related to the fact that the women in the GDM group, due to prepregnant overweight and obesity and with normal carbohydrate results in the first trimester, remained under strict control, so that from 24–28 weeks of pregnancy, after being diagnosed with GDM, they were successfully treated with not only a proper diet but also with insulin.