ZNF423 and obesity due to melanocortin 4 receptor deficiency: Previous studies assessing ex vivo adipogenic capacity of offspring gWAT in response to maternal obesity have established that epigenetic alterations in Zfp423 are required for the enhanced adipogenic capacity, though increased AP proliferation must by upstream of this event, as Zfp423, while important for adipocyte cell fate determination and commitment, has never been linked to AP proliferation [26].