Interestingly, after inclusion of LAD>40 mm, GFR<60 ml/min/1.73m2 and NT-proBNP>125 pg/ml as clinically important variables associated with AF, only LAD (OR 1.437, p = 0.102) and GFR (OR 1.603, p = 0.079) demonstrated strong associations, although these were not significant (Table 2, Model B). This evidence concerns the gene NPPB and atrial fibrillation.