Herein, we attempted to verify a possible association between pre-therapy HIV-coreceptor usage, the CD4/CD8 ratio and the VACS index at baseline and overtime to ascertain the validity of the syllogism: HIV-tropism contributes to the onset of non-AIDS events; non-AIDS events are successful predicted by the CD4/CD8 ratio and VACS index; CRT correlates with the CD4/CD8 ratio and VACS index. Here, CD4 is linked to AIDS.