This expanded study confirmed our previous report [4] linking NOD2R genotype, C. difficile infection, and IBD phenotype to ileal dysbiosis in Batch1 subjects alone, despite the addition of four additional genetic loci associated with defects in innate immunity (IRGM, CARD9, XBP1, and ORMDL3) to the analysis. The gene discussed is XBP1; the disease is inflammatory bowel disease.