VKORC1 and cancer: A previous study by de Graan et al. discovered that a set of four linked polymorphisms in VKORC1 was related to low paclitaxel clearance in a cohort of individuals with a variety of cancers.[2] In the present study, the VKORC1 SNP associated with a higher probability of toxicity, rs2884737 (T/T), is in strong linkage disequilibrium with the same allele (T/T) in rs9934438 that was associated with low clearance S1 Fig.